Celastrol CAS 34157-83-0

CAS:34157-83-0

Fomura reMamorekuru:C29H38O4

Kurema kweMorekuru:450.61

EINECS:636-472-5

Mazwi akafanana:CELASTROL(SH); CELASTROL; Celastrol (Tripterin); CELASTROL(P)(NDAPOTA FONERAI); (20R)-3-Hydroxy-2-oxo-24-nor-D:A-friedoolean-1(10),3,5,7-tetren-29-oic acid; 2-Oxo-3-hydroxy-24-norfriedela-1(10),3,5,7-tetraene-29-oic acid; 2-Oxo-3-hydroxy-24-norfriedelane-1(10),3,5,7-tetraene-29-oic acidCelasterol

Siya Mharidzo Yako

Ruzivo rweChigadzirwa

Dhawunirodha

Matagi eChigadzirwa

Chii chinonzi Celastrol CAS 34157-83-0?

Celastrol hainyungudike mumvura, inonyungudika mu dimethyl sulfoxide uye anhydrous ethanol. Inotorwa kubva muzvinhu zvinoshanda zvinorwisa kenza mumiti yakaita seThunder God Vine neSouth Snake Vine mumhuri yeCelastraceae. Inodzivirira proteasome inoshanda, yakasimbiswa kuti inokonzera apoptosis yemasero ekenza nekudzivisa kushanda kweproteasome.

Tsanangudzo

Chinhu	Tsanangudzo
Pokufashaira	645.7±55.0 °C (Yakafanotaurwa)
Kuwanda kwevanhu	1.2
Nzvimbo yekunyunguduka	219-230°C
pKa	4.78±0.70(Yakafanotaurwa)
λmax	424nm(MeOH)(yakavhenekerwa)
Mamiriro ekuchengetedza	-20°C

Kushandiswa

Celastrol inoshandiswa pakutsvaga/kuziva/kuyedza mishonga, nezvimwewo. Migumisiro yemishonga: Ine simba guru rekudzivirira kenza, mhedzisiro yekurwisa kenza angiogenesis, uye mhedzisiro yekurwisa rheumatoid. Inodzivirira proteasome inoshanda, yakasimbiswa kuti inokonzera apoptosis yemasero ekenza nekudzivisa kushanda kweproteasome.