SLU‑PP‑332 4‑Hydroxy‑N'‑(2‑naphthylmethylene)benzohydrazide CAS 303760‑60‑3

SLU-PP-332 CAS 303760-60-3imushonga une simba wekutsvaga pan-estrogen une chekuita nereceptor (ERR) agonist, upfu hwakatsetseka huchena hunobva paganda. Unoratidza hukama hwakakura neERRα, ERRβ neERRγ neEC50 values ​​ye98 nM, 230 nM uye 430 nM zvakateerana. Mushonga uyu unogona kuwedzera mashandiro emitochondrial uye kufema kwemasero mumasero emhasuru dzemapfupa, unoshandiswa zvakanyanya muongororo yezvedzidzo uye yemishonga.

Zvimiro zveChigadzirwa

✅ Kuchena kwakanyanya, kwakaedzwa neHPLC, kugadzikana kwakasimba kwebatch kusvika pabatch

✅ Bvisa data rezviitiko zvehupenyu kuti uwane tsvakiridzo yeERR

✅ Pakeji diki yerabhoritari iripo, tsigira odha yemuenzaniso

✅ Kunyungudika kwakanaka muDMSO pakugadzirwa kwekuyedza kwemasero

✅ Kurongedza kwakasimba kunodzivirira chiedza pakupisa kwakaderera kuti kuchengetwe kwenguva refu