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Kuti ganda rinyatso chengetwa zvakanaka, zvechokwadi, hazvidzivisike kuva nepfungwa yakati yezvinosanganiswa, kwete kungosimudzira chigadzirwa chete, asiwo zvinosanganiswa nechigadzirwa. Nhasi, ngatitaurei nezve "carnosine" yezvinhu zvinosanganiswa nezvigadzirwa zvekuchengetedza ganda.

Chii chinonzi 'Carnosine'
Carnosine idipeptide inoumbwa ne beta-alanine ne L-histidine, ine huwandu hwakawanda mutsandanyama nepfungwa. Carnosine ine simba re antioxidant uye inogona kubvisa ma free radicals mumuviri.

Mashandiro anoita 'carnosine'
Carnosine inogona kuwedzera simba rekudzivirira ganda, kuchengetedza masero ari madiki nekuchengetedza mashandiro emasero ari muchikamu chakazara chemasero uye mamiriro emahara, kukurudzira kugadzirwa kwecollagen, uye kuchengetedza ganda rakapfava.

Basa re'carnosine'
Carnosine inogona kuwedzera simba rekudzivirira ganda, kuchengetedza masero ari madiki nekuchengetedza mashandiro emasero ari muchikamu chakazara uye mamiriro emahara, kukurudzira kugadzirwa kwecollagen, uye kuchengetedza ganda rakapfava. Hunhu hwemakemikari hweL-carnosinendiko kuumbwa kwe beta-alanine ne L-histidine kuburikidza nekushanda kwe carnosine synthase. Carnosine ine mikana yakawanda yekushandiswa muminda yekurapa, hutano, uye hutsanana nekuda kwehunhu hwayo hwe antioxidant, mhedzisiro yekubvisa ma free radicals, chelation ne transition metals, kudzivirira tsinga, kukurudzira kuporesa maronda, uye kurwisa kukwegura.

1. Kushandiswa kwecarnosine muindasitiri yechikafu
Chinhu chikuru chiri mumafuta mukudya musanganiswa wemafuta akasiyana-siyana eglycerides ane fatty acid. Nekuda kwe free radical reaction ye unsaturated fatty acid glycerides panguva yekuchengetwa, peroxides uye omerous aldehydes kana carboxylic acids dzine short carbon chains zvinogadzirwa. Nokudaro, kudya chikafu chine fat peroxides kunowedzera kukurudzira lipid peroxidation mumiviri yevanhu uye kunokonzera zvirwere zvakasiyana-siyana. Nokudaro, butylated hydroxyanisole, dibutylated hydroxytoluene, propyl gallate, nezvimwewo zvinowanzo shandiswa mukugadzira nekuchengetedza chikafu kudzivirira mafuta peroxidation, asi kushanda kwazvo kuchadzikira mukupisa kwechikafu, uye ine chepfu yakati. L-carnosine haingodzivisi mafuta chete, asiwo ine mabasa ekuchengetedza uye ehutano. Nokudaro, L-carnosine iantioxidant yakakosha uye yakakodzera yechikafu.
2. Kushandiswa kwecarnosine mukurapa nehutano
(1) Carnosine uye Antioxidant

Carnosine haingoshandisi chete imidazole ring N atomu uye peptide bond N atomu pahistidine residues kuti ibvise ma ions esimbi uye idzivirire mafuta anokonzerwa nema ions esimbi, asiwo histidine iri padivi re carnosine ine simba rekubata hydroxyl radicals. Inogona kudzivirira mafuta anokonzerwa nema ions asiri esimbi. Saka, semushonga unoshanda we antioxidant unoshanda, carnosine inogona kuchengetedza membrane yesero uye inonyungudika mumvura, inogona kudzivirira peroxidation yemembrane yesero. Kana ichienzaniswa nemamwe ma antioxidants ebhayoloji akadai seVC, carnosine ine simba rakasimba re antioxidant. Kuwedzera pakudzivisa peroxidation process ye membrane yesero, carnosine inogonawo kudzivirira mamwe maitiro e intracellular peroxidation, kureva kuti, carnosine inogona kudzivirira nhanho yega yega ye oxidation reaction mu peroxidation chain yese mumuviri. Basa rema antioxidants akadai seVC nderekudzivirira ma free radicals kuti asapinde munyama, kureva kuti, anogona kungodzivirira maitiro emvura anobuda mumasero, uye haagone kuita chero chinhu kune ma free radicals apinda mumasero.
(2) Carnosine uye maronda emudumbu

Peptic ulcer chirwere chepasi rose chisingaperi chemudumbu, uye zvinhu chaizvo zvinokonzera maronda hazvisati zvanyatsojeka parizvino, asi pathology inotenda kuti zvinhu zvine simba (senge gastric acid, pepsin secretion, Helicobacter pylori infection) uye kudzivirira kana masero. Zvinokonzereswa nekusawirirana kwezvinhu zvinodzivirira (secretion yemucus, bicarbonate secretion, prostaglandin production). Maitiro ekudzivirira emudumbu ndeekuti: anoumba gastric mucosa yakakora inoshanda sechidziviriro chekudzivirira kuchengetedza masero ari mujira. Kubuda kwemucous membrane kunoramba kuchiitwa kunodzivirira dumbu, asi kubuda kwakanyanya kunogona kukonzera maronda emudumbu. Zvidzidzo zvakawana kuti zinc-carnosine inotorwa nechikafu inogona kudzivirira maronda zvinobudirira, inogona kuchengetedza kuvimbika kwemudumbu uye maitiro ayo ekudzivirira echisikigo, izvi zvinokonzerwa necarnosine's antioxidant properties, membrane stabilization, regulation. Pharmacological properties ye immune uye repair tissues. Sekureva kwemiedzo yekiriniki, mushure mekutora zinc-carnosine kwemavhiki masere, 70% yevarwere vakatora mushonga uyu vakaratidza kuvandudzika kukuru, uye 65% yemaronda emudumbu akavandudzika kuburikidza ne gastroscopy.
(3) Kudzora kwecarnosine uye kudzivirirwa kwezvirwere mumuviri

Kupindura kwemuviri kunoshanda mumuviri kunochengetedza homeostasis uye kunodzorwa nezvinhu zvinoshanda mumuviri muzvinhu zvipenyu. MaImmunomodulators anoreva kurapa rudzi rwezvirwere zvinokonzerwa nekusashanda zvakanaka kwemuviri, uye anoshandiswa kudzoreredza mhinduro yemuviri, kudzivirira kudzikira kwayo kusingawanzoitiki kana kudzvinyirira mhinduro yayo nekukurumidza. Mazhinji emaImmunomodulators aripo akagadzirwa nenzira dzekugadzira makemikari, ane zvimwe zvine chepfu uye migumisiro. Zvidzidzo zvakaratidza kuti carnosine ine basa rekugadzirisa muviri, uye ndiyo yega chinhu chinoshanda mumuviri chakawanikwa kusvika pari zvino chekugadzirisa muviri, uye yakashandiswa zvakanyanya mukurapa zvirwere zvakasiyana-siyana zvemuviri zvinokonzerwa nekusashanda zvakanaka kwemuviri.