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Hydroxypropyl beta-cyclodextrin, inozivikanwawo se (2-hydroxypropyl) -β-cyclodextrin, iatomu yehydrogen mumapoka e2-, 3-, uye 6-hydroxyl yeglucose residues mu β-cyclodextrin (β-CD) iyo inotsiviwa ne hydroxypropyl ku. hydroxypropoxy.HP-β-CD haina kungoita emvuropu yakanakisa mhedzisiro pamisanganiswa yakawanda senge β-CD, asi inewo zvakanakira yekunyungudika kwemvura uye kuvandudza mwero wekuburitswa uye bioavailability yemishonga yakavharirwa muvivo.Pamusoro pezvo, HP-β-CD inotora mishonga ine data rakawanda rekuchengetedza rakaunganidzwa uye hapana mhedzisiro yakaipa.HP-β-CD inogonawo kushandiswa seprotein inodzivirira uye stabilizer.

Hydroxypropyl beta-cyclodextrin yakachena kana yakachena amorphous kana crystalline powder;Kusanhuwa, kutapira zvishoma;Yakasimba mwando induction.Ichi chigadzirwa chinonyungudika nyore mumvura, chiri nyore kunyungudika mu methanol, ethanol, inenge isina kunyungudika muacetone, trichloromethane.

The solubility yehydroxypropyl -B-cyclodextrinmumvura yakanaka kwazvo, uye dhigirii yekutsiva ye4 uye pamusoro inogona kusanganiswa nemvura mune chero chikamu, uye inogona zvakare kunyungudika mu50% ethanol uye methanol.Iine imwe hama hygroscopicity.Asi hukama hwepamusoro chiitiko uye hemolytic chiitiko chakaderera.Haina kushatirwa kune tsandanyama uye ndiyo yakanaka solvent enhancer uye mishonga excipient yejekiseni.

Chii chinonzi Hydroxypropyl beta-cyclodextrin inoshandiswa?

Mumunda wezvokudya nezvinonhuwira

Hydroxypropyl beta-cyclodextrin inogona kuvandudza kugadzikana uye kushanda kwenguva refu kwemamorekuru ane hutano, kuvhara kana kugadzirisa kunhuhwirira kwakashata uye kuravira kwemamorekuru echikafu, uye kugadzirisa maitiro ekugadzira uye kunaka kwechigadzirwa.

Muzvizoro

Izvo zvigadzirwa zvezvizoro zvinogona kushandiswa sezvitsigiso, emulsifiers, deodorizers, nezvimwewo, izvo zvinogona kuderedza kukurudzira kwema organic molecules mune cosmetics paganda uye mucous membrane tishu, kuwedzera kugadzikana kwezvinhu zvinoshanda, uye kudzivirira kuvhurika uye oxidation yezvinovaka muviri. .Iine imwe hama yehygroscopicity.

Mumunda wemishonga

Hydroxypropyl beta-cyclodextrininogona kuvandudza kunyungudika kwemvura kwezvinodhaka zvisinganyunguriki, kuwedzera kugadzikana kwezvinodhaka, kuvandudza bioavailability yezvinodhaka, kuwedzera kushanda kwegadziriro yezvinodhaka kana kuderedza dosi, kugadzirisa kana kudzora kumhanya kwezvinodhaka, uye kuderedza huturu hwezvinodhaka.Inogona kushandiswa semutakuri wemishonga yemukanwa, majekiseni, mucosal zvinodhaka kuendesa masisitimu (kusanganisira nasal mucosa, rectum, cornea, nezvimwewo), transdermal absorption dhizaini nzira, lipophilic yakanangwa zvinodhaka, uye inogona zvakare kushandiswa seprotein inodzivirira uye stabilizer.